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KMID : 1161520030070030265
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Animal Cells and Systems
2003 Volume.7 No. 3 p.265 ~ p.269
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Expression of endoplasmic reticulum chaperone ERP29 in the injured spinal cord
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Park Soo-Jung
Hwang Ho-Myung
Lee Young-Ho
You Kwan-Hee
Shin Kee-Sun
Kwon O-Yu
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Abstract
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Regulation of endoplasmic reticulum (ER) chaperone, ERp29, in traumatized rat spinal cord was investigated. Compared to the control, ERp29 expression was down?regulated at the lesion site 1 d after spinal cord injury. However, ERp29 expression gradually increased from 3 d after the injury and peaked remarkably after 7 d. Two ER chaperones (GRP94 and BiP) showed constantly strong expression levels 1 d after spinal cord injury while the expression levels of the other two (calnexin and PDI) were unchanged. In the case of ERp72, its expression level was increased 1 d after the injury and gradually decreased thereafter. This study suggests that ERp29 expression in the spinal cord after traumatic injury might be associated with the posttraumatic neural survival, playing a role as a molecular chaperone.
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KEYWORD
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ERp29, Endoplasmic reticulum, Chaperone, Spinal cord Injury
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